The Eagles will be missing the man in the middle of their defense again on Monday night as linebacker Mychal Kendricks has been ruled out because of the hamstring injury he suffered in week two against the Cowboys.  Also ruled out is wide receiver Nelson Agholor, he is out with an ankle injury.

Ryan Mathews is questionable, appearing on the injury report Friday with a groin injury, he was able to practice in full on Saturday, but the workout was just a walkthrough.

Kendricks is a versatile linebacker, and he is one of two linebackers listed as inactive for Philadelphia. Kiko Alonso is also while recovering from a knee injury.

Kendricks also missed four games with a hamstring injury last year. In parts of three games this year, the inside linebacker has 17 tackles, but one area the Eagles miss with Kendricks out is his ability to blitz from up the middle and force pressure on opposing quarterbacks.

With Kendricks out, Jordan Hicks will again fill in at inside linebacker. Hicks has filled in very nicely with 27 tackles, a sack, an interception, three forced fumbles and one fumble recovery.

On the defensive line, Philadelphia will be missing Brandon Bair who exited Week 4 against the Redskins with a groin injury and hasn't played since.

(Listen to John McMullen discuss the Eagles vs Giants matchup)