Eagles vs Giants - Inactives, Keys to the Game and Pick

The Eagles host the New York Giants and their top ranked rushing defense attack, giving up just 80.6 yards per game on the ground in Week 6 at Lincoln Financial Field. On the flip side, the Giants have the 31st ranked pass defense, giving up 304 yards per game through the air.

A lot of talk this week as centered around the injuries that both teams have, specifically the Giants who will be missing cornerback Prince Amukamara, but its expected that Odell Beckham will play "barring a pregame setback." For the Eagles, Nelson Agholor and Mychal Kendricks will both miss the game, running back Ryan Mathews is listed as questionable with a groin injury.

Under the direction of Head Coach Chip Kelly, the Eagles have won three of four games against the Giants, including both games last season and have outscored New York 104-62 over the span.

Overall, Monday’s contest marks the 167th meeting between the two teams. In Philadelphia, the Eagles hold a 43-38-1 advantage, at Lincoln Financial Field, the Eagles lead the Giants, 7-6

(Listen on 97.3 ESPN, coverage starts at 7:30pm, Kickoff at 8:30pm)

The Eagles listed WR Nelson Agholor (ankle), LB Kiko Alonso (knee), DE Brandon Bair (groin), LB Mychal Kendricks (hamstring) out for the game while RB Ryan Mathews (groin) is listed as questionable, though he is expected to play on Sunday.

On the Giants injury front, Prince Amukamara will miss the game with a pectoral injury, Jayron Hosley will start in place of Amukamara. It's expected that Odell Beckham will play "barring a pregame setback."

Sal Pal’s Keys to the Game:

97.3 ESPN - Listen to Sal Pal Friday vs Giants

Eagles’ inactives: WR Nelson Agholor (ankle), QB Thad Lewis, CB Denzel Rice, ILB Kiko Alonso (knee), ILB Mychal Kendricks (hamstring), DE Brandon Bair (groin), and OL Tanner Hawkinson.

Giants’ inactives: CB Trumaine McBride, DE Robert Ayers, RCB Prince Amukamara, OL Bobby Hart, SLB Devon Kennard, WR Victor Cruz, and DT Louis Nix

Outside View: Super Bowl Champion, Howard Cross of the Giants Radio network

97.3 ESPN - Listen to the Outside View with Howard Cross

Giant to Watch: Rookie left tackle Ereck Flowers vs Fletcher Cox - Cox is coming off a NFC defensive players of the week effort, with three sacks, two forced fumbles and six tackles.

Reaction:

97.3 ESPN - Listen to ESPN.com NFL insider KC Joyner

The Eagles should be able to attack the middle of the field against the Giants, who have struggled to defend tight ends and running backs catching the ball out-of-the-backfield this season. The Giants will be missing linebacker Jon Beason in the game, the Eagles can attack that area with Zach Ertz and Darren Sproles.

"If I'm the Eagles im trying to get the ball to Sproles 10 times tonight, said ESPN.com NFL insider KC Joyner on the Sports Bash"

Last year in the season finale in New York, Jordan Matthews had 8 catches for over 100 yards and a touchdown, he could be a factor working the slot tonight with Nelson Agholor out, expect Josh Huff to have a bigger role in the game.

"If they can get Matthews open a little bit," said Barrett Brooks on the Sports Bash during Barrett Breakdown. "That could allow Josh Huff to get open and get some yards after the catch."

The Giants defend the run pretty good, so finding yards on the ground could prove to be difficult for the Eagles ground game tonight. With Mathews dinged up with a groin injury, the Eagles could lean more on DeMarco Murray in the run game, but this is a very good Giants defensive front against the run.

"The Giants are a good, legit run defense," Joyner stated. "They have been keeping the gains to a minimum."

But tonight its all about Sam Bradford, I think he shines and is the guy we are talking about tomorrow on the show.

The Pick: Eagles, 37, Giants, 24

Barrett's Breakdown for Eagles vs Giants: