The Philadelphia Eagles head up to Foxboro, MA to take on the New England Patriots on Sunday afternoon.

With Tom Brady missing key weapons such as Rob Gronkowski and Julian Edelman, you'd think the Eagles have a chance to pull of the upset.

"Did they lose Brady?"

That's the question Eagles head coach Chip Kelly asked reporters this week, unfortunately Brady expects to play for the Patriots.

That's why if the 4-7 Eagles go into Foxboro and knock off the 10-1 Patriots, it would be one of the biggest upsets of the year.

ESPN NFL insider Sal Paolantonio called into 97.3 ESPN FM for an edition of 'Sal Pal Fridays' and called it such.

"It would be the biggest upset of the year," he told Mike Gill.

The Patriots, although injured, still have an advantage over the Eagles in almost every category.

"I don't think they have it in them. I don't think they have the psychological makeup for it, the talent for it, the scheme for it, the coaches for it -- other than that I think they'll be alright," Sal Pal joked.

It's going to take all that and then some to knock off the Patriots who have lost back-to-back games just four times since 2003.

Listen to the game on 97.3 ESPN FM.