The 0-2-1 Eagles’ depth will be tested once again in San Francisco as three receivers will miss the game and Avonte Maddox is out in the secondary.

DeSean Jackson and Alshon Jeffery were both officially ruled out on Friday, today J.J. Arcega-Whiteside was added to that list.

With the three wide outs missing, the Eagles have activated five running back, MIles Sanders, Boston Scott, Corey Clement, Jason Huntley and Adrian Killins. Also at wide receiver, they have Travis Fulgham and Deontay Burnett active, joining Greg Ward and rookie John Hightower.

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Joining those three on Philadelphia's inactives list are quarterback Nate Sudfeld, tight end haleem Butler, who was acquired this week, and defensive end Casey Toohill.

Starting running back Miles Sanders, who was on the injury report this week 3 with a glute injury, is active and will play.

For the 49ers, who have a ton of injuries themselves, including quarterbaclk Jimmy Garoppolo and running back Raheem Mostert.